5IRX

Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 1	polymer	636	72959.3	4	UniProt (O35433) Pfam (PF00023) Pfam (PF00520) In PDB	Rattus norvegicus (Rat)	TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like
2	E, F	Tau-theraphotoxin-Hs1a	polymer	75	8553.0	2	UniProt (P0CH43) In PDB	Haplopelma schmidti (Chinese bird spider)	Tau-TRTX-Hs1a, Double-knot toxin, DkTx
3	A, B, C, D	(4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium	non-polymer		440.5	4	Chemie (6O8)
4	A, B, C, D, E...	(2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate	non-polymer		411.4	8	Chemie (6OE)
5	A, B, C, D	resiniferatoxin	non-polymer		628.7	4	Chemie (6EU)
6	D, E, F	(2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate	non-polymer		341.3	4	Chemie (6O9)

Sequence modifications

A, B, C, D: 110 - 603 (UniProt: O35433)

PDB	External Database	Details
Ala 106	-	expression tag
Met 107	-	expression tag
Gly 108	-	expression tag
Ser 109	-	expression tag

A, B, C, D: 627 - 764 (UniProt: O35433)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	308943.2
Non-Polymers*	Number of molecules	20
	Total formula weight	8933.4
All*	Total formula weight	317876.6

*Water molecules are not included.