5IRX
Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 1 | polymer | 636 | 72959.3 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like |
| 2 | E, F (E, F) | Tau-theraphotoxin-Hs1a | polymer | 75 | 8553.0 | 2 | UniProt (P0CH43) | Haplopelma schmidti (Chinese bird spider) | Tau-TRTX-Hs1a, Double-knot toxin, DkTx |
| 3 | G, K, N, Q (A, B, C, D) | (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium | non-polymer | 440.5 | 4 | Chemie (6O8) PubChem (119057466) PubChem (138182827) PubChem (163183407) | |||
| 4 | H, I, L, O, S... (A, B, C, D, E...) | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate | non-polymer | 411.4 | 8 | Chemie (6OE) PubChem (3080624) PubChem (101661550) PubChem (9546806) | |||
| 5 | J, M, P, U (A, B, C, D) | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) PubChem (44564218) PubChem (53776296) PubChem (57090162) PubChem (2733497) PubChem (176519982) PubChem (104826) PubChem (71718531) PubChem (5311411) PubChem (5148108) PubChem (117893115) PubChem (124525003) PubChem (5702546) PubChem (6324660) PubChem (92845090) PubChem (134688669) PubChem (15814491) PubChem (171342682) PubChem (137635852) PubChem (139248250) | |||
| 6 | R, V, X, Y (D, E, F) | (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate | non-polymer | 341.3 | 4 | Chemie (6O9) PubChem (137348500) PubChem (146171233) |
Sequence modifications
A, B, C, D: 110 - 603 (UniProt: O35433)
A, B, C, D: 627 - 764 (UniProt: O35433)
| PDB | External Database | Details |
|---|---|---|
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 308943.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 8933.4 | |
| All* | Total formula weight | 317876.6 |
