5IRZ

Structure of TRPV1 determined in lipid nanodisc

Summary for 5IRZ

Related5IRX 5IS0
EMDB information8118 8117 8119 8120 5778
DescriptorTransient receptor potential cation channel subfamily V member 1, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, ... (4 entities in total)
Functional Keywordstrp, ion channel, nanodisc, vanilloid, lipid, transport protein
Biological sourceRattus norvegicus (Rat)
Cellular locationCell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein  O35433
Total number of polymer chains4
Total molecular weight302472.31
Authors
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2016-03-15, release date: 2016-05-25, Last modification date: 2017-09-13)
Primary citation
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y.
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534:347-351, 2016
PubMed: 27281200 (PDB entries with the same primary citation)
DOI: 10.1038/nature17964
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.28 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers700MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 5irz
no rotation
Molmil generated image of 5irz
rotated about x axis by 90°
Molmil generated image of 5irz
rotated about y axis by 90°
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan