Structure of TRPV1 determined in lipid nanodisc

Summary for 5IRZ

Related5IRX 5IS0
EMDB information8118 8117 8119 8120 5778
DescriptorTransient receptor potential cation channel subfamily V member 1, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, ... (4 entities in total)
Functional Keywordstrp, ion channel, nanodisc, vanilloid, lipid, transport protein
Biological sourceRattus norvegicus (Rat)
Cellular locationCell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein  O35433
Total number of polymer chains4
Total molecular weight302472.31
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2016-03-15, release date: 2016-05-25, Last modification date: 2017-09-13)
Primary citation
Gao, Y.,Cao, E.,Julius, D.,Cheng, Y.
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534:347-351, 2016
PubMed: 27281200 (PDB entries with the same primary citation)
DOI: 10.1038/nature17964
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers700MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

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