5IRZ
Structure of TRPV1 determined in lipid nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (D, E, B, C) | Transient receptor potential cation channel subfamily V member 1 | polymer | 636 | 72959.3 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like |
| 2 | E, K, Q, W (D, E, B, C) | (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium | non-polymer | 440.5 | 4 | Chemie (6O8) | |||
| 3 | F, L, R, X (D, E, B, C) | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate | non-polymer | 572.6 | 4 | Chemie (6ES) | |||
| 4 | AA, BA, G, H, I... (C, D, E, B) | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate | non-polymer | 411.4 | 16 | Chemie (6OE) |
Sequence modifications
D, E, B, C: 110 - 603 (UniProt: O35433)
D, E, B, C: 627 - 764 (UniProt: O35433)
| PDB | External Database | Details |
|---|---|---|
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 291837.2 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 10635.1 | |
| All* | Total formula weight | 302472.3 |
