Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IRZ

Structure of TRPV1 determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
E	0005216	molecular_function	monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 6O8 D 801

Chain	Residue
D	ASN437
D	VAL440
D	PHE488
D	ARG491
D	GLU513
D	PHE516
D	TYR554
D	TYR555

site_id	AC2
Number of Residues	9
Details	binding site for residue 6ES D 802

Chain	Residue
D	SER510
D	TYR511
D	SER512
D	THR550
D	ARG557
D	GLU570
D	LEU699
D	GLN700
D	ASP509

site_id	AC3
Number of Residues	3
Details	binding site for residue 6OE D 803

Chain	Residue
B	6OE803
D	TYR631
E	ALA657

site_id	AC4
Number of Residues	1
Details	binding site for residue 6OE D 804

Chain	Residue
D	PHE655

site_id	AC5
Number of Residues	6
Details	binding site for residue 6OE D 805

Chain	Residue
D	TYR453
D	TYR454
D	6OE806
E	PHE589
E	SER629
E	6OE806

site_id	AC6
Number of Residues	5
Details	binding site for residue 6OE D 806

Chain	Residue
D	TYR454
D	GLY470
D	PHE473
D	ARG474
D	6OE805

site_id	AC7
Number of Residues	8
Details	binding site for residue 6O8 E 801

Chain	Residue
E	ASN437
E	VAL440
E	PHE488
E	ARG491
E	GLU513
E	PHE516
E	TYR554
E	TYR555

site_id	AC8
Number of Residues	9
Details	binding site for residue 6ES E 802

Chain	Residue
E	ASP509
E	SER510
E	TYR511
E	SER512
E	THR550
E	ARG557
E	GLU570
E	LEU699
E	GLN700

site_id	AC9
Number of Residues	1
Details	binding site for residue 6OE E 803

Chain	Residue
E	PHE655

site_id	AD1
Number of Residues	6
Details	binding site for residue 6OE E 804

Chain	Residue
C	PHE589
C	SER629
C	6OE805
E	TYR453
E	TYR454
E	6OE805

site_id	AD2
Number of Residues	5
Details	binding site for residue 6OE E 805

Chain	Residue
E	TYR454
E	GLY470
E	PHE473
E	ARG474
E	6OE804

site_id	AD3
Number of Residues	3
Details	binding site for residue 6OE E 806

Chain	Residue
C	ALA657
D	6OE805
E	TYR631

site_id	AD4
Number of Residues	9
Details	binding site for residue 6ES B 802

Chain	Residue
B	ASP509
B	SER510
B	TYR511
B	SER512
B	THR550
B	ARG557
B	GLU570
B	LEU699
B	GLN700

site_id	AD5
Number of Residues	6
Details	binding site for residue 6OE B 803

Chain	Residue
B	TYR453
B	TYR454
B	6OE804
D	PHE589
D	SER629
D	6OE803

site_id	AD6
Number of Residues	5
Details	binding site for residue 6OE B 804

Chain	Residue
B	TYR454
B	GLY470
B	PHE473
B	ARG474
B	6OE803

site_id	AD7
Number of Residues	3
Details	binding site for residue 6OE B 805

Chain	Residue
B	TYR631
C	6OE803
D	ALA657

site_id	AD8
Number of Residues	1
Details	binding site for residue 6OE B 806

Chain	Residue
B	PHE655

site_id	AD9
Number of Residues	9
Details	binding site for residue 6ES C 802

Chain	Residue
C	ASP509
C	SER510
C	TYR511
C	SER512
C	THR550
C	ARG557
C	GLU570
C	LEU699
C	GLN700

site_id	AE1
Number of Residues	6
Details	binding site for residue 6OE C 803

Chain	Residue
B	6OE805
C	TYR453
C	TYR454
C	6OE804
B	PHE589
B	SER629

site_id	AE2
Number of Residues	5
Details	binding site for residue 6OE C 804

Chain	Residue
C	TYR454
C	GLY470
C	PHE473
C	ARG474
C	6OE803

site_id	AE3
Number of Residues	3
Details	binding site for residue 6OE C 805

Chain	Residue
B	ALA657
C	TYR631
E	6OE804

site_id	AE4
Number of Residues	1
Details	binding site for residue 6OE C 806

Chain	Residue
C	PHE655

site_id	AE5
Number of Residues	14
Details	binding site for Di-peptide 6O8 B 801 and ARG B 491

Chain	Residue
B	ASN437
B	VAL440
B	TYR487
B	PHE488
B	PHE489
B	PHE490
B	GLY492
B	ILE493
B	GLN494
B	TYR495
B	GLU513
B	PHE516
B	TYR554
B	TYR555

site_id	AE6
Number of Residues	14
Details	binding site for Di-peptide 6O8 B 801 and PHE B 516

Chain	Residue
B	ASN437
B	VAL440
B	PHE488
B	ARG491
B	SER512
B	GLU513
B	ILE514
B	LEU515
B	PHE517
B	VAL518
B	SER520
B	ASN551
B	TYR554
B	TYR555

site_id	AE7
Number of Residues	14
Details	binding site for Di-peptide 6O8 C 801 and PHE C 516

Chain	Residue
C	ASN437
C	VAL440
C	PHE488
C	ARG491
C	SER512
C	GLU513
C	ILE514
C	LEU515
C	PHE517
C	VAL518
C	SER520
C	ASN551
C	TYR554
C	TYR555

site_id	AE8
Number of Residues	14
Details	binding site for Di-peptide 6O8 C 801 and ARG C 491

Chain	Residue
C	ASN437
C	VAL440
C	TYR487
C	PHE488
C	PHE489
C	PHE490
C	GLY492
C	ILE493
C	GLN494
C	TYR495
C	GLU513
C	PHE516
C	TYR554
C	TYR555

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	104
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	88
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	92
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	112
Details	Region: {"description":"AD","evidences":[{"source":"PubMed","id":"15190102","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"10931826","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by PKA; in vitro","evidences":[{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"11884385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)