Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IRZ

Structure of TRPV1 determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005216	molecular_function	monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 6O8 D 801

Chain	Residue
D	ASN437
D	VAL440
D	PHE488
D	ARG491
D	GLU513
D	PHE516
D	TYR554
D	TYR555

site_id	AC2
Number of Residues	9
Details	binding site for residue 6ES D 802

Chain	Residue
D	SER510
D	TYR511
D	SER512
D	THR550
D	ARG557
D	GLU570
D	LEU699
D	GLN700
D	ASP509

site_id	AC3
Number of Residues	3
Details	binding site for residue 6OE D 803

Chain	Residue
B	6OE803
D	TYR631
E	ALA657

site_id	AC4
Number of Residues	1
Details	binding site for residue 6OE D 804

Chain	Residue
D	PHE655

site_id	AC5
Number of Residues	6
Details	binding site for residue 6OE D 805

Chain	Residue
D	TYR453
D	TYR454
D	6OE806
E	PHE589
E	SER629
E	6OE806

site_id	AC6
Number of Residues	5
Details	binding site for residue 6OE D 806

Chain	Residue
D	TYR454
D	GLY470
D	PHE473
D	ARG474
D	6OE805

site_id	AC7
Number of Residues	8
Details	binding site for residue 6O8 E 801

Chain	Residue
E	ASN437
E	VAL440
E	PHE488
E	ARG491
E	GLU513
E	PHE516
E	TYR554
E	TYR555

site_id	AC8
Number of Residues	9
Details	binding site for residue 6ES E 802

Chain	Residue
E	ASP509
E	SER510
E	TYR511
E	SER512
E	THR550
E	ARG557
E	GLU570
E	LEU699
E	GLN700

site_id	AC9
Number of Residues	1
Details	binding site for residue 6OE E 803

Chain	Residue
E	PHE655

site_id	AD1
Number of Residues	6
Details	binding site for residue 6OE E 804

Chain	Residue
C	PHE589
C	SER629
C	6OE805
E	TYR453
E	TYR454
E	6OE805

site_id	AD2
Number of Residues	5
Details	binding site for residue 6OE E 805

Chain	Residue
E	TYR454
E	GLY470
E	PHE473
E	ARG474
E	6OE804

site_id	AD3
Number of Residues	3
Details	binding site for residue 6OE E 806

Chain	Residue
C	ALA657
D	6OE805
E	TYR631

site_id	AD4
Number of Residues	9
Details	binding site for residue 6ES B 802

Chain	Residue
B	ASP509
B	SER510
B	TYR511
B	SER512
B	THR550
B	ARG557
B	GLU570
B	LEU699
B	GLN700

site_id	AD5
Number of Residues	6
Details	binding site for residue 6OE B 803

Chain	Residue
B	TYR453
B	TYR454
B	6OE804
D	PHE589
D	SER629
D	6OE803

site_id	AD6
Number of Residues	5
Details	binding site for residue 6OE B 804

Chain	Residue
B	TYR454
B	GLY470
B	PHE473
B	ARG474
B	6OE803

site_id	AD7
Number of Residues	3
Details	binding site for residue 6OE B 805

Chain	Residue
B	TYR631
C	6OE803
D	ALA657

site_id	AD8
Number of Residues	1
Details	binding site for residue 6OE B 806

Chain	Residue
B	PHE655

site_id	AD9
Number of Residues	9
Details	binding site for residue 6ES C 802

Chain	Residue
C	ASP509
C	SER510
C	TYR511
C	SER512
C	THR550
C	ARG557
C	GLU570
C	LEU699
C	GLN700

site_id	AE1
Number of Residues	6
Details	binding site for residue 6OE C 803

Chain	Residue
B	6OE805
C	TYR453
C	TYR454
C	6OE804
B	PHE589
B	SER629

site_id	AE2
Number of Residues	5
Details	binding site for residue 6OE C 804

Chain	Residue
C	TYR454
C	GLY470
C	PHE473
C	ARG474
C	6OE803

site_id	AE3
Number of Residues	3
Details	binding site for residue 6OE C 805

Chain	Residue
B	ALA657
C	TYR631
E	6OE804

site_id	AE4
Number of Residues	1
Details	binding site for residue 6OE C 806

Chain	Residue
C	PHE655

site_id	AE5
Number of Residues	14
Details	binding site for Di-peptide 6O8 B 801 and ARG B 491

Chain	Residue
B	ASN437
B	VAL440
B	TYR487
B	PHE488
B	PHE489
B	PHE490
B	GLY492
B	ILE493
B	GLN494
B	TYR495
B	GLU513
B	PHE516
B	TYR554
B	TYR555

site_id	AE6
Number of Residues	14
Details	binding site for Di-peptide 6O8 B 801 and PHE B 516

Chain	Residue
B	ASN437
B	VAL440
B	PHE488
B	ARG491
B	SER512
B	GLU513
B	ILE514
B	LEU515
B	PHE517
B	VAL518
B	SER520
B	ASN551
B	TYR554
B	TYR555

site_id	AE7
Number of Residues	14
Details	binding site for Di-peptide 6O8 C 801 and PHE C 516

Chain	Residue
C	ASN437
C	VAL440
C	PHE488
C	ARG491
C	SER512
C	GLU513
C	ILE514
C	LEU515
C	PHE517
C	VAL518
C	SER520
C	ASN551
C	TYR554
C	TYR555

site_id	AE8
Number of Residues	14
Details	binding site for Di-peptide 6O8 C 801 and ARG C 491

Chain	Residue
C	ASN437
C	VAL440
C	TYR487
C	PHE488
C	PHE489
C	PHE490
C	GLY492
C	ILE493
C	GLN494
C	TYR495
C	GLU513
C	PHE516
C	TYR554
C	TYR555

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200

Chain	Residue	Details
D	ILE433-TYR453
E	GLU536-THR556
E	MET572-ILE599
E	VAL658-VAL686
B	ILE433-TYR453
B	TYR472-LEU497
B	TYR511-PHE531
B	GLU536-THR556
B	MET572-ILE599
B	VAL658-VAL686
C	ILE433-TYR453
D	TYR472-LEU497
C	TYR472-LEU497
C	TYR511-PHE531
C	GLU536-THR556
C	MET572-ILE599
C	VAL658-VAL686
D	TYR511-PHE531
D	GLU536-THR556
D	MET572-ILE599
D	VAL658-VAL686
E	ILE433-TYR453
E	TYR472-LEU497
E	TYR511-PHE531

site_id	SWS_FT_FI2
Number of Residues	184
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200

Chain	Residue	Details
D	TYR454-ASP471
C	TYR454-ASP471
C	SER532-LYS535
C	GLU600-PHE649
D	SER532-LYS535
D	GLU600-PHE649
E	TYR454-ASP471
E	SER532-LYS535
E	GLU600-PHE649
B	TYR454-ASP471
B	SER532-LYS535
B	GLU600-PHE649

site_id	SWS_FT_FI3
Number of Residues	104
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200

Chain	Residue	Details
D	GLN498-SER510
D	ARG557-LYS571
E	GLN498-SER510
E	ARG557-LYS571
B	GLN498-SER510
B	ARG557-LYS571
C	GLN498-SER510
C	ARG557-LYS571

site_id	SWS_FT_FI4
Number of Residues	88
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0000305\|PubMed:10931826

Chain	Residue	Details
D	TYR627-PHE649
E	TYR627-PHE649
B	TYR627-PHE649
C	TYR627-PHE649

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2PNN

Chain	Residue	Details
D	ARG115
C	ARG115
C	LYS155
C	GLU210
D	LYS155
D	GLU210
E	ARG115
E	LYS155
E	GLU210
B	ARG115
B	LYS155
B	GLU210

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2NYJ, ECO:0007744\|PDB:2PNN

Chain	Residue	Details
D	LYS160
C	LYS160
C	ASN164
C	TYR199
D	ASN164
D	TYR199
E	LYS160
E	ASN164
E	TYR199
B	LYS160
B	ASN164
B	TYR199

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:5IRX

Chain	Residue	Details
D	TYR511
C	TYR511
C	THR550
C	ARG557
D	THR550
D	ARG557
E	TYR511
E	THR550
E	ARG557
B	TYR511
B	THR550
B	ARG557

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9R186

Chain	Residue	Details
D	ASP646
E	ASP646
B	ASP646
C	ASP646

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269\|PubMed:12194871, ECO:0000269\|PubMed:15471852

Chain	Residue	Details
D	SER116
E	SER116
B	SER116
C	SER116

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269\|PubMed:12194871

Chain	Residue	Details
D	THR144
D	THR370
E	THR144
E	THR370
B	THR144
B	THR370
C	THR144
C	THR370

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269\|PubMed:11884385, ECO:0000269\|PubMed:12194871, ECO:0000269\|PubMed:14630912

Chain	Residue	Details
D	SER502
E	SER502
B	SER502
C	SER502

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:14630912

Chain	Residue	Details
D	THR704
E	THR704
B	THR704
C	THR704

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:11683872

Chain	Residue	Details
D	TYR627
E	TYR627
B	TYR627
C	TYR627

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)