8VPP

Phosphorylated human NCC in complex with chlorthalidone

Summary for 8VPP

Entry DOI	10.2210/pdb8vpp/pdb
EMDB information	43412
Descriptor	Solute carrier family 12 member 3, 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide (3 entities in total)
Functional Keywords	sodium chloride cotransporter, phosphorylation, thiazide-like diuretics, chlorthalidone, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	227068.06
Authors	Zhao, Y.X.,Cao, E.H. (deposition date: 2024-01-16, release date: 2024-09-04)
Primary citation	Zhao, Y.,Schubert, H.,Blakely, A.,Forbush, B.,Smith, M.D.,Rinehart, J.,Cao, E. Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15:7006-7006, 2024 Cited by PubMed: 39143061 DOI: 10.1038/s41467-024-51381-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation