9BWT
human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide
Summary for 9BWT
| Entry DOI | 10.2210/pdb9bwt/pdb |
| EMDB information | 44979 |
| Descriptor | Solute carrier family 12 member 3, ADENOSINE-5'-TRIPHOSPHATE, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ... (4 entities in total) |
| Functional Keywords | sodium chloride cotransporter, phosphorylation, thiazide diuretics, transport protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 228125.46 |
| Authors | Cao, E.H.,Zhao, Y.X. (deposition date: 2024-05-21, release date: 2024-09-04, Last modification date: 2024-10-09) |
| Primary citation | Zhao, Y.,Schubert, H.,Blakely, A.,Forbush, B.,Smith, M.D.,Rinehart, J.,Cao, E. Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15:7006-7006, 2024 Cited by PubMed: 39143061DOI: 10.1038/s41467-024-51381-y PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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