6WB8

Cryo-EM structure of PKD2 C331S disease variant

Summary for 6WB8

Entry DOI	10.2210/pdb6wb8/pdb
EMDB information	21586
Descriptor	Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	pkd2, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	348722.62
Authors	Cao, E.,Wang, J.,Decaen, P.G. (deposition date: 2020-03-26, release date: 2020-04-22, Last modification date: 2020-07-29)
Primary citation	Vien, T.N.,Wang, J.,Ng, L.C.T.,Cao, E.,DeCaen, P.G. Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain. Proc.Natl.Acad.Sci.USA, 117:10329-10338, 2020 Cited by PubMed: 32332171 DOI: 10.1073/pnas.1920777117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.24 Å)

Structure validation