6WB8
Cryo-EM structure of PKD2 C331S disease variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Polycystin-2 | polymer | 756 | 86517.0 | 4 | UniProt (Q13563) Pfam (PF20519) Pfam (PF00520) Pfam (PF08016) | Homo sapiens (Human) | PC2,Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2 |
| 2 | E, F, G, H, I... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 41 - 792 (UniProt: Q13563)
| PDB | External Database | Details |
|---|---|---|
| Gly 37 | - | expression tag |
| Met 38 | - | expression tag |
| Gly 39 | - | expression tag |
| Ser 40 | - | expression tag |
| Ser 331 | Cys 331 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 346068.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2654.5 | |
| All* | Total formula weight | 348722.6 |
