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PDB: 151 results

6F0X
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BU of 6f0x by Molmil
Cryo-EM structure of TRIP13 in complex with ATP gamma S, p31comet, C-Mad2 and Cdc20
Descriptor: Cell division cycle protein 20 homolog, MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, ...
Authors:Alfieri, C, Chang, L, Barford, D.
Deposit date:2017-11-20
Release date:2018-05-02
Last modified:2020-12-02
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.
Nature, 559, 2018
8QRY
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BU of 8qry by Molmil
Crystal structure of the yeast spindle body component Spc98
Descriptor: Spindle pole body component
Authors:Bellini, D, Yatskevich, S, Barford, D.
Deposit date:2023-10-09
Release date:2024-04-03
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure of the yeast spindle body component Spc98
To Be Published
1BZC
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BU of 1bzc by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
Authors:Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZH
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BU of 1bzh by Molmil
Cyclic peptide inhibitor of human PTP1B
Descriptor: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B)
Authors:Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D.
Deposit date:1998-10-28
Release date:1999-02-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1A5Y
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BU of 1a5y by Molmil
PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE
Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Pannifer, A.D.P, Flint, A.J, Tonks, N.K, Barford, D.
Deposit date:1998-02-19
Release date:1998-06-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
J.Biol.Chem., 273, 1998
1ABB
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BU of 1abb by Molmil
CONTROL OF PHOSPHORYLASE B CONFORMATION BY A MODIFIED COFACTOR: CRYSTALLOGRAPHIC STUDIES ON R-STATE GLYCOGEN PHOSPHORYLASE RECONSTITUTED WITH PYRIDOXAL 5'-DIPHOSPHATE
Descriptor: GLYCOGEN PHOSPHORYLASE B, INOSINIC ACID, PYRIDOXAL-5'-DIPHOSPHATE, ...
Authors:Leonidas, D.D, Oikonomakos, N.G, Papageorgiou, A.C, Acharya, K.R, Barford, D, Johnson, L.N.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate.
Protein Sci., 1, 1992
8Q84
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BU of 8q84 by Molmil
Outer kinetochore Dam1 protomer dimer Ndc80-Nuf2 coiled-coil complex
Descriptor: DASH complex subunit ASK1, DASH complex subunit DAD1, DASH complex subunit DAD2, ...
Authors:Muir, K.W, Barford, D.
Deposit date:2023-08-17
Release date:2023-12-06
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules.
Science, 382, 2023
8QAU
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BU of 8qau by Molmil
Outer kinetochore Ndc80-Dam1 alpha/beta-tubulin complex
Descriptor: DASH complex subunit DAM1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Muir, K.W, Barford, D.
Deposit date:2023-08-23
Release date:2024-04-03
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction
Biorxiv, 2023
3ZJE
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BU of 3zje by Molmil
A20 OTU domain in reversibly oxidised (SOH) state
Descriptor: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
Authors:Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
Deposit date:2013-01-17
Release date:2013-03-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
8Q85
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BU of 8q85 by Molmil
Outer kinetochore Dam1 protomer monomer Ndc80-Nuf2 coiled-coil complex
Descriptor: DASH complex subunit ASK1, DASH complex subunit DAD1, DASH complex subunit DAD2, ...
Authors:Muir, K.W, Barford, D.
Deposit date:2023-08-17
Release date:2023-12-06
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules.
Science, 382, 2023
3ZJD
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BU of 3zjd by Molmil
A20 OTU domain in reduced, active state at 1.87 A resolution
Descriptor: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
Authors:Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
Deposit date:2013-01-17
Release date:2013-03-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
8S4G
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BU of 8s4g by Molmil
Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D.
Deposit date:2024-02-21
Release date:2024-03-13
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex
To Be Published
4ADY
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BU of 4ady by Molmil
Crystal structure of 26S proteasome subunit Rpn2
Descriptor: 26S PROTEASOME REGULATORY SUBUNIT RPN2
Authors:Kulkarni, K, He, J, Da Fonseca, P.C.A, Krutauz, D, Glickman, M.H, Barford, D, Morris, E.P.
Deposit date:2012-01-04
Release date:2012-03-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
3ZJF
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BU of 3zjf by Molmil
A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak.
Descriptor: A20P50, CHLORIDE ION
Authors:Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
Deposit date:2013-01-17
Release date:2013-03-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJG
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BU of 3zjg by Molmil
A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak.
Descriptor: CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
Authors:Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
Deposit date:2013-01-17
Release date:2013-03-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
1W9H
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BU of 1w9h by Molmil
The Structure of a Piwi protein from Archaeoglobus fulgidus.
Descriptor: CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ...
Authors:Parker, J.S, Roe, S.M, Barford, D.
Deposit date:2004-10-13
Release date:2005-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
6TGB
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BU of 6tgb by Molmil
CryoEM structure of the binary DOCK2-ELMO1 complex
Descriptor: Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1
Authors:Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D.
Deposit date:2019-11-15
Release date:2020-07-29
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
6TGC
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BU of 6tgc by Molmil
CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex.
Descriptor: Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1
Authors:Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D.
Deposit date:2019-11-15
Release date:2020-07-29
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
6TLJ
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BU of 6tlj by Molmil
Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Alfieri, C, Barford, D.
Deposit date:2019-12-02
Release date:2020-02-19
Last modified:2020-06-17
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Embo Rep., 21, 2020
6TM5
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BU of 6tm5 by Molmil
Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Alfieri, C, Barford, D.
Deposit date:2019-12-03
Release date:2020-02-19
Last modified:2020-06-17
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Embo Rep., 21, 2020
2JF5
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BU of 2jf5 by Molmil
crystal structure of Lys63-linked di-ubiquitin
Descriptor: CADMIUM ION, CHLORIDE ION, COBALT (II) ION, ...
Authors:Komander, D, Odenwaelder, P, Barford, D.
Deposit date:2007-01-26
Release date:2008-02-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
1FQ1
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BU of 1fq1 by Molmil
CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-DEPENDENT KINASE INHIBITOR 3, ...
Authors:Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D.
Deposit date:2000-09-01
Release date:2001-05-09
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Mol.Cell, 7, 2001
1FPZ
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BU of 1fpz by Molmil
CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE
Descriptor: CYCLIN-DEPENDENT KINASE INHIBITOR 3, SULFATE ION
Authors:Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D.
Deposit date:2000-09-01
Release date:2001-05-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Mol.Cell, 7, 2001
1B3U
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BU of 1b3u by Molmil
CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
Descriptor: PROTEIN (PROTEIN PHOSPHATASE PP2A)
Authors:Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D.
Deposit date:1998-12-14
Release date:1999-04-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
1G1H
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BU of 1g1h by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor: BI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000

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