1G1H

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE

Summary for 1G1H
DescriptorPROTEIN TYROSINE PHOSPHATASE 1B, BI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE (3 entities in total)
Functional Keywordshydrolase (phosphorylation), tyrosine phosphatase, peptide complex, hydrolase, signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains2
Total formula weight36351.15
Authors
Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D. (deposition date: 2000-10-11, release date: 2001-01-17, Last modification date: 2011-07-13)
Primary citationAndersen, J.N.,Barford, D.,Myers, M.P.,Salmeen, A.,Tonks, N.K.
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6:1401-1412, 2000
PubMed: 11163213
DOI: 110.1016/S1097-2765(00)00137-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation
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PDB entries from 2021-06-16