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6HN5
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BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
著者Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
登録日2018-09-14
公開日2018-11-21
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
6HN4
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BU of 6hn4 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4
著者Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
登録日2018-09-14
公開日2018-11-21
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
4ZXB
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BU of 4zxb by Molmil
Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Croll, T, Smith, B.J, Margetts, M.B, Whittaker, J, Weiss, M.A, Ward, C.W, Lawrence, M.C.
登録日2015-05-20
公開日2016-02-24
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24, 2016
5KQV
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BU of 5kqv by Molmil
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ...
著者Lawrence, M.C, Smith, B.J, Croll, T.I.
登録日2016-07-06
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
7S0Q
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BU of 7s0q by Molmil
Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
著者Xu, Y, Lawrence, M.C.
登録日2021-08-30
公開日2022-07-06
最終更新日2022-08-17
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022
5J3H
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BU of 5j3h by Molmil
Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lawrence, M, Menting, J, Lawrence, C.
登録日2016-03-30
公開日2016-06-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.27 Å)
主引用文献Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
J.Biol.Chem., 291, 2016
8DI2
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BU of 8di2 by Molmil
Site 2 insulin receptor binding peptide IM459N21
分子名称: Site 2 binding peptide IM459N21
著者Lawrence, M.C, Hu, H, Martinez, F.J, Espinosa, J.F.
登録日2022-06-28
公開日2022-11-09
実験手法SOLUTION NMR
主引用文献Activation of the human insulin receptor by non-insulin-related peptides.
Nat Commun, 13, 2022
7S8V
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BU of 7s8v by Molmil
Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
著者Xu, Y, Lawrence, M.C.
登録日2021-09-20
公開日2022-07-06
最終更新日2022-08-17
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022
7U6D
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BU of 7u6d by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
分子名称: IM459, Isoform Short of Insulin receptor
著者Kirk, N.S, Lawrence, M.C.
登録日2022-03-03
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (5.03 Å)
主引用文献Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
7U6E
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BU of 7u6e by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ...
著者Kirk, N.S, Lawrence, M.C.
登録日2022-03-03
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
4XST
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BU of 4xst by Molmil
Structure of the endoglycosidase-H treated L1-CR domains of the human insulin receptor in complex with residues 697-719 of the human insulin receptor (A-isoform)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, SULFATE ION, ...
著者Menting, J.G, Lawrence, C.F, Kong, G.K.-W, Lawrence, M.C.
登録日2015-01-22
公開日2015-06-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
Structure, 23, 2015
4XSS
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BU of 4xss by Molmil
Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
著者Lawrence, C, Kong, G.K.-W, Menting, J.G, Lawrence, M.C.
登録日2015-01-22
公開日2015-06-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
Structure, 23, 2015
5U8Q
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BU of 5u8q by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
著者Lawrence, M, Xu, Y.
登録日2016-12-14
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.2710402 Å)
主引用文献How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
5U8R
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BU of 5u8r by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
著者Lawrence, M, Xu, Y.
登録日2016-12-14
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.00001621 Å)
主引用文献How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
6VWI
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BU of 6vwi by Molmil
Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
著者Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
登録日2020-02-19
公開日2020-05-13
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWH
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BU of 6vwh by Molmil
Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
分子名称: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
著者Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
登録日2020-02-19
公開日2020-05-13
最終更新日2020-07-22
実験手法ELECTRON MICROSCOPY (4.26 Å)
主引用文献How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWG
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BU of 6vwg by Molmil
Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
著者Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
登録日2020-02-19
公開日2020-05-13
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.21 Å)
主引用文献How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWJ
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BU of 6vwj by Molmil
Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II
分子名称: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
著者Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
登録日2020-02-19
公開日2020-05-13
最終更新日2020-07-22
実験手法ELECTRON MICROSCOPY (4.21 Å)
主引用文献How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
3W11
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BU of 3w11 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
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BU of 3w13 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J, Brzozowski, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (4.303 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
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BU of 3w12 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J, Brzozowsk, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (4.301 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013

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