8VJC
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![BU of 8vjc by Molmil](/molmil-images/mine/8vjc) | Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | Descriptor: | Insulin-like growth factor II, Isoform Short of Insulin receptor | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2024-01-06 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8VJB
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![BU of 8vjb by Molmil](/molmil-images/mine/8vjb) | Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | Descriptor: | Insulin-like growth factor II, Isoform Short of Insulin receptor | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2024-01-06 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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7TYM
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![BU of 7tym by Molmil](/molmil-images/mine/7tym) | Cryo-EM Structure of insulin receptor-related receptor (IRR) in active-state captured at pH 9. The 3D refinement was applied with C2 symmetry | Descriptor: | Insulin receptor-related protein | Authors: | Wang, L.W, Hall, C, Li, J, Choi, E, Bai, X.C. | Deposit date: | 2022-02-13 | Release date: | 2023-02-15 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat.Struct.Mol.Biol., 30, 2023
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7TYJ
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![BU of 7tyj by Molmil](/molmil-images/mine/7tyj) | Cryo-EM Structure of insulin receptor-related receptor (IRR) in apo-state captured at pH 7. The 3D refinement was focused on one of two halves with C1 symmetry applied | Descriptor: | Insulin receptor-related protein | Authors: | Wang, L.W, Hall, C, Li, J, Choi, E, Bai, X.C. | Deposit date: | 2022-02-13 | Release date: | 2023-02-15 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat.Struct.Mol.Biol., 30, 2023
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7TYK
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![BU of 7tyk by Molmil](/molmil-images/mine/7tyk) | Cryo-EM Structure of insulin receptor-related receptor (IRR) in apo-state captured at pH 7. The 3D refinement was applied with C2 symmetry | Descriptor: | Insulin receptor-related protein | Authors: | Wang, L.W, Hall, C, Li, J, Choi, E, Bai, X.C. | Deposit date: | 2022-02-13 | Release date: | 2023-02-15 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat.Struct.Mol.Biol., 30, 2023
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8U4C
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![BU of 8u4c by Molmil](/molmil-images/mine/8u4c) | Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. | Descriptor: | Insulin receptor, Insulin-like growth factor II | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2023-09-10 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4B
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![BU of 8u4b by Molmil](/molmil-images/mine/8u4b) | Cryo-EM structure of long form insulin receptor (IR-B) in the apo state | Descriptor: | Insulin receptor | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2023-09-10 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4E
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![BU of 8u4e by Molmil](/molmil-images/mine/8u4e) | Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation. | Descriptor: | Insulin receptor, Insulin-like growth factor II | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2023-09-10 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8DTM
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![BU of 8dtm by Molmil](/molmil-images/mine/8dtm) | Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 | Descriptor: | Insulin mimetic peptide S597 component 2, Insulin receptor | Authors: | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | Deposit date: | 2022-07-26 | Release date: | 2022-09-07 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
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8DTL
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![BU of 8dtl by Molmil](/molmil-images/mine/8dtl) | Cryo-EM structure of insulin receptor (IR) bound with S597 peptide | Descriptor: | Insulin mimetic peptide S597, Insulin receptor | Authors: | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | Deposit date: | 2022-07-25 | Release date: | 2022-09-07 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
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8EYX
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![BU of 8eyx by Molmil](/molmil-images/mine/8eyx) | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EZ0
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![BU of 8ez0 by Molmil](/molmil-images/mine/8ez0) | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYY
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![BU of 8eyy by Molmil](/molmil-images/mine/8eyy) | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYR
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![BU of 8eyr by Molmil](/molmil-images/mine/8eyr) | Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-28 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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3TCM
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![BU of 3tcm by Molmil](/molmil-images/mine/3tcm) | Crystal Structure of Alanine Aminotransferase from Hordeum vulgare | Descriptor: | Alanine aminotransferase 2, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE | Authors: | Rydel, T.J, Sturman, E.J, Halls, C, Chen, S, Zeng, J, Evdokimov, A, Duff, S.M.G. | Deposit date: | 2011-08-09 | Release date: | 2012-07-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | The Enzymology of alanine aminotransferase (AlaAT) isoforms from Hordeum vulgare and other organisms, and the HvAlaAT crystal structure. Arch.Biochem.Biophys., 528, 2012
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5NFO
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![BU of 5nfo by Molmil](/molmil-images/mine/5nfo) | |
5NFN
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![BU of 5nfn by Molmil](/molmil-images/mine/5nfn) | |
8SBD
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![BU of 8sbd by Molmil](/molmil-images/mine/8sbd) | Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C. | Deposit date: | 2023-04-03 | Release date: | 2023-08-30 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of insulin fibrillation. Sci Adv, 9, 2023
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4HWS
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![BU of 4hws by Molmil](/molmil-images/mine/4hws) | |
4HWP
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![BU of 4hwp by Molmil](/molmil-images/mine/4hwp) | |
4HWT
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![BU of 4hwt by Molmil](/molmil-images/mine/4hwt) | |
4HWR
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![BU of 4hwr by Molmil](/molmil-images/mine/4hwr) | |
4HWO
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![BU of 4hwo by Molmil](/molmil-images/mine/4hwo) | |
4RHZ
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![BU of 4rhz by Molmil](/molmil-images/mine/4rhz) | Crystal structure of Cry23Aa1 and Cry37Aa1 binary protein complex | Descriptor: | CALCIUM ION, Cry23AA1, Cry37AA1, ... | Authors: | Rydel, T.J, Williams, J.M, Brown, G.R, Guzov, V.M, Sturman, E.J, Evdokimov, A. | Deposit date: | 2014-10-03 | Release date: | 2015-10-28 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The Associated Bacillus thuringiensis Binary Protein Complex of Cry23Aa1 and Cry37Aa1: Crystal Structure, Insecticidal Data, and Pore Formation Modeling. To be Published
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7YXK
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![BU of 7yxk by Molmil](/molmil-images/mine/7yxk) | |