7TYJ
Cryo-EM Structure of insulin receptor-related receptor (IRR) in apo-state captured at pH 7. The 3D refinement was focused on one of two halves with C1 symmetry applied
Summary for 7TYJ
| Entry DOI | 10.2210/pdb7tyj/pdb |
| EMDB information | 26181 |
| Descriptor | Insulin receptor-related protein (1 entity in total) |
| Functional Keywords | receptor tyrosine kinase, insulin receptor family, signaling protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 287759.09 |
| Authors | Wang, L.W.,Hall, C.,Li, J.,Choi, E.,Bai, X.C. (deposition date: 2022-02-13, release date: 2023-02-15, Last modification date: 2023-05-31) |
| Primary citation | Wang, L.,Hall, C.,Li, J.,Choi, E.,Bai, X.C. Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat.Struct.Mol.Biol., 30:661-669, 2023 Cited by PubMed: 37055497DOI: 10.1038/s41594-023-00974-0 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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