Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Summary for 4BVD

Related4BV5 4BV7 4BVC 4BVV 4BVW
DescriptorAPOLIPOPROTEIN(A), CHLORIDE ION, 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide, ... (4 entities in total)
Functional Keywordshydrolase, cardiovascular disease, optical biosensors
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight9550.35
Primary citation
Sandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W.
Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208401.4%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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