Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Summary for 4BV7

Related4BV5 4BVC 4BVD 4BVV 4BVW
DescriptorAPOLIPOPROTEIN(A), ACETATE ION, 3-(4-piperidyl)propanoic acid, ... (4 entities in total)
Functional Keywordshydrolase, lipoprotein(a), cardiovascular disease, drug discovery, optical biosensors
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight9431.38
Primary citation
Sandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W.
Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.202501.4%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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