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4BVV

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Summary for 4BVV
Entry DOI10.2210/pdb4bvv/pdb
Related4BV5 4BV7 4BVC 4BVD 4BVW
DescriptorAPOLIPOPROTEIN(A), 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase, cardiovascular disease, drug discovery, optical biosensors
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight9613.78
Authors
Primary citationSandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W.
Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published,
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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PDB entries from 2024-03-27

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