4BV5

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Summary for 4BV5

Related4BV7 4BVC 4BVD 4BVV 4BVW
DescriptorAPOLIPOPROTEIN(A), 4-(aminomethyl)-N-(benzenesulfonyl)cyclohexanecarboxamide (3 entities in total)
Functional Keywordshydrolase, cardiovascular disease, optical biosensors
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight18904.93
Authors
Primary citation
Sandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W.
Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.230406.4%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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