4BV5
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | APOLIPOPROTEIN(A) | polymer | 79 | 9156.1 | 2 | UniProt (P08519) Pfam (PF00051) | HOMO SAPIENS (HUMAN) | APO(A), LP(A) |
| 2 | C, D (A, B) | 4-(aminomethyl)-N-(benzenesulfonyl)cyclohexanecarboxamide | non-polymer | 296.4 | 2 | Chemie (5C3) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 80 (UniProt: P08519)
| PDB | External Database | Details |
|---|---|---|
| Ala 76 | Asn 4197 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 18312.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 592.8 | |
| All* | Total formula weight | 18904.9 |
