1UOM

The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand.

Summary for 1UOM

Entry DOI	10.2210/pdb1uom/pdb
Related	1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1QKT 1QKU 3ERD 3ERT
Descriptor	ESTROGEN RECEPTOR, 2-PHENYL-1-[4-(2-PIPERIDIN-1-YL-ETHOXY)-PHENYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL (3 entities in total)
Functional Keywords	selective estrogen receptor modulators, serm, receptor, transcription regulation, dna-binding, nuclear protein, zinc-finger, steroid-binding, phosphorylation, polymorphism 3d-structure, alternative splicing
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
Total number of polymer chains	1
Total formula weight	29400.59
Authors	Stark, W.,Bischoff, S.F.,Buhl, T.,Fournier, B.,Halleux, C.,Kallen, J.,Keller, H.,Renaud, J. (deposition date: 2003-04-11, release date: 2003-07-03, Last modification date: 2023-12-13)
Primary citation	Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Halleux, C.,Kallen, J.,Keller, H.,Schlaeppi, J.-M.,Stark, W. Estrogen Receptor Modulators: Identification and Structure-Activity Relationships of Potent Eralpha-Selective Tetrahydroisoquinoline Ligands J.Med.Chem., 46:2945-, 2003 Cited by PubMed: 12825935 DOI: 10.1021/JM030086H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation