1GWR

HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE

Summary for 1GWR

Entry DOI	10.2210/pdb1gwr/pdb
Related	1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1HCP 1HCQ 1QKT 1QKU 3ERD 3ERT
Descriptor	OESTROGEN RECEPTOR, TRANSCRIPTION INTERMEDIARY FACTOR-2, ESTRADIOL, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, transactivation, agonist, af2 coactivator, receptor, activator, transcripti regulation, dna-binding, nuclear protein, zinc finger, ster binding, phosphorylation, polymorphism, alternative splicing
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	58771.40
Authors	Pike, A.C.W.,Brzozowski, A.M. (deposition date: 2002-03-22, release date: 2002-08-29, Last modification date: 2023-12-13)
Primary citation	Warnmark, A.,Treuter, E.,Gustafsson, J.-A.,Hubbard, R.E.,Brzozowski, A.M.,Pike, A.C.W. Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha. J.Biol.Chem., 277:21862-, 2002 Cited by PubMed: 11937504 DOI: 10.1074/JBC.M200764200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation