1UOM

The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ESTROGEN RECEPTOR	polymer	254	28972.0	1	UniProt (P03372) Pfam (PF00104) In PDB	HOMO SAPIENS (HUMAN)	ESTROGEN RECEPTOR ALPHA, ER, ESTRADIOL RECEPTOR, ER-ALPHA, ESR1, NR3A1, ESR
2	A	2-PHENYL-1-[4-(2-PIPERIDIN-1-YL-ETHOXY)-PHENYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL	non-polymer		428.6	1	Chemie (PTI)
3		water	water		18.0	89	Chemie (HOH)

Sequence modifications

A: 300 - 300 (PDB: 1UOM)
A: 301 - 553 (UniProt: P03372)

PDB	External Database	Details
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 530	Cys 530	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28972.0
Non-Polymers*	Number of molecules	1
	Total formula weight	428.6
All*	Total formula weight	29400.6

*Water molecules are not included.