1UOM
The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ESTROGEN RECEPTOR | polymer | 254 | 28972.0 | 1 | UniProt (P03372) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | ESTROGEN RECEPTOR ALPHA, ER, ESTRADIOL RECEPTOR, ER-ALPHA, ESR1, NR3A1, ESR |
| 2 | B (A) | 2-PHENYL-1-[4-(2-PIPERIDIN-1-YL-ETHOXY)-PHENYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL | non-polymer | 428.6 | 1 | Chemie (PTI) | |||
| 3 | C (A) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 300 - 300 (PDB: 1UOM)
A: 301 - 553 (UniProt: P03372)
A: 301 - 553 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28972.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 428.6 | |
| All* | Total formula weight | 29400.6 |
