1UOM
The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand.
Summary for 1UOM
Entry DOI | 10.2210/pdb1uom/pdb |
Related | 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1QKT 1QKU 3ERD 3ERT |
Descriptor | ESTROGEN RECEPTOR, 2-PHENYL-1-[4-(2-PIPERIDIN-1-YL-ETHOXY)-PHENYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL (3 entities in total) |
Functional Keywords | selective estrogen receptor modulators, serm, receptor, transcription regulation, dna-binding, nuclear protein, zinc-finger, steroid-binding, phosphorylation, polymorphism 3d-structure, alternative splicing |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 1 |
Total formula weight | 29400.59 |
Authors | Stark, W.,Bischoff, S.F.,Buhl, T.,Fournier, B.,Halleux, C.,Kallen, J.,Keller, H.,Renaud, J. (deposition date: 2003-04-11, release date: 2003-07-03, Last modification date: 2023-12-13) |
Primary citation | Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Halleux, C.,Kallen, J.,Keller, H.,Schlaeppi, J.-M.,Stark, W. Estrogen Receptor Modulators: Identification and Structure-Activity Relationships of Potent Eralpha-Selective Tetrahydroisoquinoline Ligands J.Med.Chem., 46:2945-, 2003 Cited by PubMed: 12825935DOI: 10.1021/JM030086H PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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