1XQC

X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution

Summary for 1XQC

Entry DOI	10.2210/pdb1xqc/pdb
Related	1UOM
Descriptor	Estrogen receptor, (1S)-1-{4-[(9AR)-OCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-2-YL]PHENYL}-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL (3 entities in total)
Functional Keywords	alpha-helical sandwich, nuclear hormone receptor, ligand binding domain, hormone receptor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
Total number of polymer chains	4
Total formula weight	117646.45
Authors	Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Geiser, M.,Halleux, C.,Kallen, J.,Keller, H.J.,Ramage, P. (deposition date: 2004-10-12, release date: 2005-02-01, Last modification date: 2023-10-25)
Primary citation	Renaud, J.,Bischoff, S.F.,Buhl, T.,Floersheim, P.,Fournier, B.,Geiser, M.,Halleux, C.,Kallen, J.,Keller, H.J.,Ramage, P. Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure-Activity Relationship of ERalpha-Selective Tetrahydroisoquinoline Ligands J.Med.Chem., 48:364-379, 2005 Cited by PubMed: 15658851 DOI: 10.1021/jm040858p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation