1XQC
X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 254 | 28972.0 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | estrogen receptor alpha, ER, Estradiol receptor, ER-alpha |
| 2 | E, F, G, H (A, B, C, D) | (1S)-1-{4-[(9AR)-OCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-2-YL]PHENYL}-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL | non-polymer | 439.6 | 4 | Chemie (AEJ) PubChem (21158749) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 301 - 553 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 300 | - | initiating methionine |
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 115888.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1758.4 | |
| All* | Total formula weight | 117646.5 |
