1XQC
X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AEJ A 1001 |
| Chain | Residue |
| A | LEU346 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | TRP383 |
| A | LEU387 |
| A | ARG394 |
| A | LEU536 |
| A | HOH1003 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AEJ B 2001 |
| Chain | Residue |
| B | LEU346 |
| B | THR347 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | TRP383 |
| B | ARG394 |
| B | MET421 |
| B | GLY521 |
| B | HIS524 |
| B | LEU525 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AEJ C 3001 |
| Chain | Residue |
| C | LEU346 |
| C | ALA350 |
| C | ASP351 |
| C | GLU353 |
| C | TRP383 |
| C | ARG394 |
| C | GLY420 |
| C | GLY521 |
| C | HIS524 |
| C | LEU525 |
| C | HOH3003 |
| C | HOH3072 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AEJ D 4001 |
| Chain | Residue |
| D | LEU346 |
| D | ALA350 |
| D | ASP351 |
| D | GLU353 |
| D | LEU354 |
| D | TRP383 |
| D | ARG394 |
| D | MET421 |
| D | HIS524 |
| D | LEU536 |
| D | HOH4009 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| D | GLU353 | |
| D | ARG394 | |
| D | HIS524 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 | |
| C | GLU353 | |
| C | ARG394 | |
| C | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR537 | |
| C | TYR537 | |
| D | TYR537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
| C | CYS447 | |
| D | CYS447 |
