1B2T
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3UCR
| Crystal structure of the immunoreceptor TIGIT IgV domain | Descriptor: | CHLORIDE ION, T cell immunoreceptor with Ig and ITIM domains | Authors: | Yin, J.P, Stengel, K.F, Rouge, L, Bazan, J.F, Wiesmann, C. | Deposit date: | 2011-10-27 | Release date: | 2012-03-14 | Last modified: | 2012-04-25 | Method: | X-RAY DIFFRACTION (2.627 Å) | Cite: | Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DKF
| Crystal Structure of Human Interleukin-34 Bound to FAb2 | Descriptor: | FAb2 Heavy Chain, FAb2 Light Chain, Interleukin-34, ... | Authors: | Ma, X, Chen, Y, Stawicki, S, Wu, Y, Bazan, J.F, Starovasnik, M.A. | Deposit date: | 2012-02-03 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
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4DKE
| Crystal Structure of Human Interleukin-34 Bound to FAb1.1 | Descriptor: | FAb1.1 Heavy Chain, FAb1.1 Light Chain, Interleukin-34, ... | Authors: | Ma, X, Chen, Y, Stawicki, S, Wu, Y, Bazan, J.F, Starovasnik, M.A. | Deposit date: | 2012-02-03 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
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4DKC
| Crystal Structure of Human Interleukin-34 | Descriptor: | Interleukin-34, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Ma, X, Bazan, J.F, Starovasnik, M.A. | Deposit date: | 2012-02-03 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
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4DKD
| Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-34, ... | Authors: | Ma, X, Bazan, J.F, Starovasnik, M.A. | Deposit date: | 2012-02-03 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R. Structure, 20, 2012
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1I1J
| STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS | Descriptor: | MELANOMA DERIVED GROWTH REGULATORY PROTEIN | Authors: | Lougheed, J.C, Holton, J.M, Alber, T, Bazan, J.F, Handel, T.M. | Deposit date: | 2001-02-02 | Release date: | 2001-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proc.Natl.Acad.Sci.USA, 98, 2001
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1OZN
| 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination | Descriptor: | ACETIC ACID, Reticulon 4 receptor, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | He, X, Bazan, J.F, Park, J.B, McDermott, G, He, Z, Garcia, K.C. | Deposit date: | 2003-04-09 | Release date: | 2003-05-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structure of the Nogo Receptor Ectodomain. A Recognition module implicated in Myelin Inhibition. Neuron, 38, 2003
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3UDW
| Crystal structure of the immunoreceptor TIGIT in complex with Poliovirus receptor (PVR/CD155/necl-5) D1 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Poliovirus receptor, T cell immunoreceptor with Ig and ITIM domains | Authors: | Rouge, L, Stengel, K.F, Yin, J.P, Bazan, F.J, Wiesmann, C. | Deposit date: | 2011-10-28 | Release date: | 2012-03-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.903 Å) | Cite: | Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc.Natl.Acad.Sci.USA, 109, 2012
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2QQL
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2QQO
| Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | Authors: | Appleton, B.A, Wiesmann, C. | Deposit date: | 2007-07-26 | Release date: | 2007-11-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007
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2QQJ
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2QQM
| Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Appleton, B.A, Wiesmann, C. | Deposit date: | 2007-07-26 | Release date: | 2007-11-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007
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2QQN
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2QQK
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2QQI
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7ZG0
| Murine IL-27 in complex with IL-27Ra and a non-competing Nb | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | Authors: | Skladanowska, K, Bloch, Y, Savvides, S.N. | Deposit date: | 2022-04-01 | Release date: | 2022-11-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41, 2022
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7ZXK
| Human IL-27 in complex with neutralizing SRF388 FAb fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, ... | Authors: | Bloch, Y, Skladanowska, K, Strand, J, Welin, M, Logan, D, Hill, J, Savvides, S.N. | Deposit date: | 2022-05-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41, 2022
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3V42
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2KJX
| Solution structure of the extracellular domain of JTB | Descriptor: | Jumping translocation breakpoint protein | Authors: | Rousseau, F, Lingel, A, Pan, B, Fairbrother, W.J, Bazan, F. | Deposit date: | 2009-06-10 | Release date: | 2010-08-11 | Last modified: | 2012-04-18 | Method: | SOLUTION NMR | Cite: | The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. J.Mol.Biol., 415, 2012
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7NX4
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7NX2
| Unbound antigen-binding fragment (FAb) 324 | Descriptor: | FAb 324 Heavy Chain, FAb 324 Light Chain, SULFATE ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NWZ
| ALK:ALKAL2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK and LTK ligand 2, ALK tyrosine kinase receptor | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.17 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX0
| LTK:ALKAL1 complex stabilized by a Nanobody | Descriptor: | ALK and LTK ligand 1, Leukocyte tyrosine kinase receptor, Nb3.16, ... | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX1
| TG domain of LTK | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Leukocyte tyrosine kinase receptor, TERBIUM(III) ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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