7ZXK

Human IL-27 in complex with neutralizing SRF388 FAb fragment

Summary for 7ZXK

• Entry DOI: 10.2210/pdb7zxk/pdb
• Related: 7zg0
• Descriptor: Interleukin-27 subunit alpha, Interleukin-27 subunit beta, SRF388 Heavy Chain, ... (6 entities in total)
• Functional Keywords: cytokine, heterodimer, neutralizing, antibody
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 192673.51

Authors

Bloch, Y.,Skladanowska, K.,Strand, J.,Welin, M.,Logan, D.,Hill, J.,Savvides, S.N. (deposition date: 2022-05-21, release date: 2022-11-02, Last modification date: 2024-01-31)

• Primary citation: Skladanowska, K.,Bloch, Y.,Strand, J.,White, K.F.,Hua, J.,Aldridge, D.,Welin, M.,Logan, D.T.,Soete, A.,Merceron, R.,Murphy, C.,Provost, M.,Bazan, J.F.,Hunter, C.A.,Hill, J.A.,Savvides, S.N.; Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.; Cell Rep, 41:111490-111490, 2022; PubMed: 36261006; DOI: 10.1016/j.celrep.2022.111490

Experimental method

X-RAY DIFFRACTION (2.2 Å)