7ZG0
Murine IL-27 in complex with IL-27Ra and a non-competing Nb
Summary for 7ZG0
Entry DOI | 10.2210/pdb7zg0/pdb |
Descriptor | Interleukin-27 subunit alpha, Interleukin-27 subunit beta, Interleukin-27 receptor subunit alpha, ... (7 entities in total) |
Functional Keywords | cytokine, receptor, heterodimer, cancer, glycoprotein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 8 |
Total formula weight | 195869.86 |
Authors | Skladanowska, K.,Bloch, Y.,Savvides, S.N. (deposition date: 2022-04-01, release date: 2022-11-02, Last modification date: 2024-05-01) |
Primary citation | Skladanowska, K.,Bloch, Y.,Strand, J.,White, K.F.,Hua, J.,Aldridge, D.,Welin, M.,Logan, D.T.,Soete, A.,Merceron, R.,Murphy, C.,Provost, M.,Bazan, J.F.,Hunter, C.A.,Hill, J.A.,Savvides, S.N. Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41:111490-111490, 2022 Cited by PubMed: 36261006DOI: 10.1016/j.celrep.2022.111490 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.18 Å) |
Structure validation
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