7ZG0

Murine IL-27 in complex with IL-27Ra and a non-competing Nb

Summary for 7ZG0

• Entry DOI: 10.2210/pdb7zg0/pdb
• Descriptor: Interleukin-27 subunit alpha, Interleukin-27 subunit beta, Interleukin-27 receptor subunit alpha, ... (7 entities in total)
• Functional Keywords: cytokine, receptor, heterodimer, cancer, glycoprotein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 8
• Total formula weight: 195869.86

Authors

Skladanowska, K.,Bloch, Y.,Savvides, S.N. (deposition date: 2022-04-01, release date: 2022-11-02)

• Primary citation: Skladanowska, K.,Bloch, Y.,Strand, J.,White, K.F.,Hua, J.,Aldridge, D.,Welin, M.,Logan, D.T.,Soete, A.,Merceron, R.,Murphy, C.,Provost, M.,Bazan, J.F.,Hunter, C.A.,Hill, J.A.,Savvides, S.N.; Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.; Cell Rep, 41:111490-111490, 2022; PubMed: 36261006; DOI: 10.1016/j.celrep.2022.111490

Experimental method

X-RAY DIFFRACTION (3.18 Å)