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7ZXK

Human IL-27 in complex with neutralizing SRF388 FAb fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0002230biological_processpositive regulation of defense response to virus by host
A0002376biological_processimmune system process
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0009617biological_processresponse to bacterium
A0009986cellular_componentcell surface
A0032729biological_processpositive regulation of type II interferon production
A0042129biological_processregulation of T cell proliferation
A0045087biological_processinnate immune response
A0045523molecular_functioninterleukin-27 receptor binding
A0045625biological_processregulation of T-helper 1 cell differentiation
A0050688biological_processregulation of defense response to virus
A0050863biological_processregulation of T cell activation
A0140459biological_processresponse to Gram-positive bacterium
B0002376biological_processimmune system process
B0004896molecular_functioncytokine receptor activity
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005788cellular_componentendoplasmic reticulum lumen
B0005886cellular_componentplasma membrane
B0006959biological_processhumoral immune response
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
B0019221biological_processcytokine-mediated signaling pathway
B0032729biological_processpositive regulation of type II interferon production
B0042088biological_processT-helper 1 type immune response
B0042098biological_processT cell proliferation
B0045523molecular_functioninterleukin-27 receptor binding
B0046641biological_processpositive regulation of alpha-beta T cell proliferation
C0002230biological_processpositive regulation of defense response to virus by host
C0002376biological_processimmune system process
C0005102molecular_functionsignaling receptor binding
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005788cellular_componentendoplasmic reticulum lumen
C0005829cellular_componentcytosol
C0006954biological_processinflammatory response
C0007165biological_processsignal transduction
C0009617biological_processresponse to bacterium
C0009986cellular_componentcell surface
C0032729biological_processpositive regulation of type II interferon production
C0042129biological_processregulation of T cell proliferation
C0045087biological_processinnate immune response
C0045523molecular_functioninterleukin-27 receptor binding
C0045625biological_processregulation of T-helper 1 cell differentiation
C0050688biological_processregulation of defense response to virus
C0050863biological_processregulation of T cell activation
C0140459biological_processresponse to Gram-positive bacterium
D0002376biological_processimmune system process
D0004896molecular_functioncytokine receptor activity
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005788cellular_componentendoplasmic reticulum lumen
D0005886cellular_componentplasma membrane
D0006959biological_processhumoral immune response
D0007165biological_processsignal transduction
D0016020cellular_componentmembrane
D0019221biological_processcytokine-mediated signaling pathway
D0032729biological_processpositive regulation of type II interferon production
D0042088biological_processT-helper 1 type immune response
D0042098biological_processT cell proliferation
D0045523molecular_functioninterleukin-27 receptor binding
D0046641biological_processpositive regulation of alpha-beta T cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR207-HIS213
ITYR198-HIS204

site_idPS01354
Number of Residues41
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPegVrlsplaerq..LqvqWepPgSWpfpei.FsLkYwI
ChainResidueDetails
BILE127-ILE167

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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