7NX2
| Unbound antigen-binding fragment (FAb) 324 | Descriptor: | FAb 324 Heavy Chain, FAb 324 Light Chain, SULFATE ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX3
| Crystal structure of ALK in complex with Fab324 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK tyrosine kinase receptor, Fab324 HeavyChain, ... | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX0
| LTK:ALKAL1 complex stabilized by a Nanobody | Descriptor: | ALK and LTK ligand 1, Leukocyte tyrosine kinase receptor, Nb3.16, ... | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX4
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7NWZ
| ALK:ALKAL2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK and LTK ligand 2, ALK tyrosine kinase receptor | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.17 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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7NX1
| TG domain of LTK | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Leukocyte tyrosine kinase receptor, TERBIUM(III) ION | Authors: | De Munck, S, Savvides, S.N. | Deposit date: | 2021-03-17 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600, 2021
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4WRL
| Structure of the human CSF-1:CSF-1R complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor, ... | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | Deposit date: | 2014-10-24 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.802 Å) | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure, 23, 2015
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4WRM
| Structure of the human CSF-1:CSF-1R complex | Descriptor: | Macrophage colony-stimulating factor 1, Macrophage colony-stimulating factor 1 receptor | Authors: | Felix, J, De Munck, S, Elegheert, J, Savvides, S.N. | Deposit date: | 2014-10-24 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (6.853 Å) | Cite: | Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure, 23, 2015
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6YIG
| Crystal structure of the N-terminal EF-hand domain of Arabidopsis thaliana AtEH1/Pan1 | Descriptor: | CALCIUM ION, Calcium-binding EF hand family protein, SODIUM ION | Authors: | Yperman, K, Merceron, R, De Munck, S, Bloch, Y, Savvides, S.N, Pleskot, R, Van Damme, D. | Deposit date: | 2020-04-01 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding. Nat Commun, 12, 2021
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6YT1
| Mtb TMK crystal structure in complex with compound 26 | Descriptor: | 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase | Authors: | Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N. | Deposit date: | 2020-04-23 | Release date: | 2020-09-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur.J.Med.Chem., 206, 2020
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