7NX3

Crystal structure of ALK in complex with Fab324

Summary for 7NX3

Entry DOI	10.2210/pdb7nx3/pdb
Related	7NWZ 7NX0 7NX1 7NX2 7NX4
Descriptor	ALK tyrosine kinase receptor, Fab324 HeavyChain, Fab324 Light Chain, ... (4 entities in total)
Functional Keywords	cell surface receptor cytokine binding, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	179638.22
Authors	De Munck, S.,Savvides, S.N. (deposition date: 2021-03-17, release date: 2021-10-27, Last modification date: 2024-01-31)
Primary citation	De Munck, S.,Provost, M.,Kurikawa, M.,Omori, I.,Mukohyama, J.,Felix, J.,Bloch, Y.,Abdel-Wahab, O.,Bazan, J.F.,Yoshimi, A.,Savvides, S.N. Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600:143-147, 2021 Cited by PubMed: 34646012 DOI: 10.1038/s41586-021-03959-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation