7NX4
Crystal structure of the TG and EGF-like domains of ALK
Summary for 7NX4
Entry DOI | 10.2210/pdb7nx4/pdb |
Related | 7NWZ 7NX0 7NX1 7NX2 7NX3 |
Descriptor | ALK tyrosine kinase receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total) |
Functional Keywords | cell surface receptor cytokine binding, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41567.29 |
Authors | De Munck, S.,Savvides, S.N. (deposition date: 2021-03-17, release date: 2021-10-27, Last modification date: 2024-01-31) |
Primary citation | De Munck, S.,Provost, M.,Kurikawa, M.,Omori, I.,Mukohyama, J.,Felix, J.,Bloch, Y.,Abdel-Wahab, O.,Bazan, J.F.,Yoshimi, A.,Savvides, S.N. Structural basis of cytokine-mediated activation of ALK family receptors. Nature, 600:143-147, 2021 Cited by PubMed: 34646012DOI: 10.1038/s41586-021-03959-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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