7NX4

Crystal structure of the TG and EGF-like domains of ALK

Summary for 7NX4

• Entry DOI: 10.2210/pdb7nx4/pdb
• Related: 7NWZ 7NX0 7NX1 7NX2 7NX3
• Descriptor: ALK tyrosine kinase receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• Functional Keywords: cell surface receptor cytokine binding, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41567.29

Authors

De Munck, S.,Savvides, S.N. (deposition date: 2021-03-17, release date: 2021-10-27, Last modification date: 2024-01-31)

• Primary citation: De Munck, S.,Provost, M.,Kurikawa, M.,Omori, I.,Mukohyama, J.,Felix, J.,Bloch, Y.,Abdel-Wahab, O.,Bazan, J.F.,Yoshimi, A.,Savvides, S.N.; Structural basis of cytokine-mediated activation of ALK family receptors.; Nature, 600:143-147, 2021; PubMed: 34646012; DOI: 10.1038/s41586-021-03959-5

Experimental method

X-RAY DIFFRACTION (3 Å)