7NX3

Crystal structure of ALK in complex with Fab324

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	ALK tyrosine kinase receptor	polymer	389	40499.7	2	UniProt (Q9UM73) Pfam (PF12810) In PDB	Homo sapiens (Human)	Anaplastic lymphoma kinase
2	B, E	Fab324 HeavyChain	polymer	231	24516.2	2		Mus musculus
3	C, D	Fab324 Light Chain	polymer	218	23918.4	2		Mus musculus
4	A, F	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)

Sequence modifications

A, F: 648 - 1030 (UniProt: Q9UM73)

PDB	External Database	Details
Gly 1031	-	expression tag
Thr 1032	-	expression tag
Asp 1033	-	expression tag
Glu 1034	-	expression tag
Val 1035	-	expression tag
Asp 1036	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	177868.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1769.7
All*	Total formula weight	179638.2

*Water molecules are not included.