2QQN

Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab

Summary for 2QQN

• Entry DOI: 10.2210/pdb2qqn/pdb
• Related: 2QQI 2QQJ 2QQK 2QQL 2QQM 2QQO
• Descriptor: Neuropilin-1, Antibody heavy chain, Antibody light chain, ... (5 entities in total)
• Functional Keywords: vegf receptor, semaphorin receptor, phage-derived antibody, angiogenesis, developmental protein, differentiation, glycoprotein, heparan sulfate, membrane, neurogenesis, proteoglycan, secreted, transmembrane, hormone, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: O14786
• Total number of polymer chains: 3
• Total formula weight: 65785.67

Authors

Appleton, B.A.,Wiesmann, C. (deposition date: 2007-07-26, release date: 2007-11-20, Last modification date: 2023-08-30)

• Primary citation: Appleton, B.A.,Wu, P.,Maloney, J.,Yin, J.,Liang, W.C.,Stawicki, S.,Mortara, K.,Bowman, K.K.,Elliott, J.M.,Desmarais, W.,Bazan, J.F.,Bagri, A.,Tessier-Lavigne, M.,Koch, A.W.,Wu, Y.,Watts, R.J.,Wiesmann, C.; Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding; Embo J., 26:4902-4912, 2007; PubMed: 17989695; DOI: 10.1038/sj.emboj.7601906

Experimental method

X-RAY DIFFRACTION (2.2 Å)