2QQN

Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO L 215

Chain	Residue
L	GLY200
L	LEU201
L	SER202

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO H 221

Chain	Residue
H	ALA53
H	GLY54
H	ALA71
H	PHE29
H	SER30
H	TYR32
H	MET34
H	SER52
H	PRO52

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 3

Chain	Residue
A	ALA293
A	SER295
A	GLN296
H	TYR99
H	HOH265
L	TYR32

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR194-HIS200

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site_id	PS01285
Number of Residues	30
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. GWtpgedsyre......WIqVDlgllrfVtaVgTQG

Chain	Residue	Details
A	GLY314-GLY343

---

site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Patwetgis..MRfEVyGC

Chain	Residue	Details
A	PRO408-CYS424

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"F5/8 type C 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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