4DKD

Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R

Summary for 4DKD

• Entry DOI: 10.2210/pdb4dkd/pdb
• Descriptor: Interleukin-34, Macrophage colony-stimulating factor 1 receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: dimeric four-helix bundle cytokine, receptor tyrosine kinase, glycosylation, cytokine-transferase complex, cytokine/transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 77006.20

Authors

Ma, X.,Bazan, J.F.,Starovasnik, M.A. (deposition date: 2012-02-03, release date: 2012-04-11, Last modification date: 2020-07-29)

• Primary citation: Ma, X.,Lin, W.Y.,Chen, Y.,Stawicki, S.,Mukhyala, K.,Wu, Y.,Martin, F.,Bazan, J.F.,Starovasnik, M.A.; Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.; Structure, 20:676-687, 2012; PubMed: 22483114; DOI: 10.1016/j.str.2012.02.010

Experimental method

X-RAY DIFFRACTION (3 Å)