4DKD

Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-34	polymer	185	21434.5	2	UniProt (Q6ZMJ4) Pfam (PF15036)	Homo sapiens (human)	IL-34
2	C (C)	Macrophage colony-stimulating factor 1 receptor	polymer	292	32043.2	1	UniProt (P07333) Pfam (PF00047)	Homo sapiens (human)	CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms
3	D, E (D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	F, G (A, B)	beta-D-mannopyranose	non-polymer		180.2	2	Chemie (BMA)
5	H, I, J, K (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
6	L, M, N (A, B, C)	water	water		18.0	16	Chemie (HOH)

Sequence modifications

A, B: 21 - 193 (UniProt: Q6ZMJ4)

PDB	External Database	Details
Ala 18	-	expression tag
Gly 19	-	expression tag
Ser 20	-	expression tag
Gly 194	-	expression tag
Asn 195	-	expression tag
Ser 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag

C: 20 - 299 (UniProt: P07333)

PDB	External Database	Details
Ala 17	-	expression tag
Gly 18	-	expression tag
Ser 19	-	expression tag
Gly 300	-	expression tag
Asn 301	-	expression tag
Ser 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	74912.3
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1245.1
All*	Total formula weight	77006.2

*Water molecules are not included.