3UCR
Crystal structure of the immunoreceptor TIGIT IgV domain
Summary for 3UCR
| Entry DOI | 10.2210/pdb3ucr/pdb |
| Descriptor | T cell immunoreceptor with Ig and ITIM domains, CHLORIDE ION (3 entities in total) |
| Functional Keywords | pvr/tigit/nectins/ig superfamily/signal transduction, igsf, immuno receptor, pvr, nectin-2, nectin-3, membrane protein, signaling protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane; Single-pass type I membrane protein: Q495A1 |
| Total number of polymer chains | 4 |
| Total formula weight | 48192.78 |
| Authors | Yin, J.P.,Stengel, K.F.,Rouge, L.,Bazan, J.F.,Wiesmann, C. (deposition date: 2011-10-27, release date: 2012-03-14, Last modification date: 2012-04-25) |
| Primary citation | Stengel, K.F.,Harden-Bowles, K.,Yu, X.,Rouge, L.,Yin, J.,Comps-Agrar, L.,Wiesmann, C.,Bazan, J.F.,Eaton, D.L.,Grogan, J.L. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc.Natl.Acad.Sci.USA, 109:5399-5404, 2012 Cited by PubMed: 22421438DOI: 10.1073/pnas.1120606109 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.627 Å) |
Structure validation
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