2QQL

Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab

Summary for 2QQL

Related2QQI 2QQJ 2QQK 2QQM 2QQN 2QQO
DescriptorNeuropilin-2, Antibody Heavy Chain, Antibody Light Chain (3 entities in total)
Functional Keywordsvegf receptor, semaphorin receptor, phage-derived antibody, developmental protein, differentiation, glycoprotein, membrane, neurogenesis, transmembrane, hormone, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane ; Single-pass type I membrane protein . Isoform s9: Secreted  O60462
Total number of polymer chains3
Total molecular weight113576.04
Authors
Appleton, B.A.,Wiesmann, C. (deposition date: 2007-07-26, release date: 2007-11-20, Last modification date: 2017-10-25)
Primary citation
Appleton, B.A.,Wu, P.,Maloney, J.,Yin, J.,Liang, W.C.,Stawicki, S.,Mortara, K.,Bowman, K.K.,Elliott, J.M.,Desmarais, W.,Bazan, J.F.,Bagri, A.,Tessier-Lavigne, M.,Koch, A.W.,Wu, Y.,Watts, R.J.,Wiesmann, C.
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26:4902-4912, 2007
PubMed: 17989695 (PDB entries with the same primary citation)
DOI: 10.1038/sj.emboj.7601906
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23581.5%8.0%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 2qql
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2qql.pdb2.gz [157.51 KB])
Coordinate files for Biological unit (2qql.pdb1.gz [309.96 KB])
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