2QQL

Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab

Summary for 2QQL

• Entry DOI: 10.2210/pdb2qql/pdb
• Related: 2QQI 2QQJ 2QQK 2QQM 2QQN 2QQO
• Descriptor: Neuropilin-2, Antibody Heavy Chain, Antibody Light Chain (3 entities in total)
• Functional Keywords: vegf receptor, semaphorin receptor, phage-derived antibody, developmental protein, differentiation, glycoprotein, membrane, neurogenesis, transmembrane, hormone, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane ; Single-pass type I membrane protein . Isoform s9: Secreted : O60462
• Total number of polymer chains: 3
• Total formula weight: 113576.04

Authors

Appleton, B.A.,Wiesmann, C. (deposition date: 2007-07-26, release date: 2007-11-20, Last modification date: 2023-08-30)

• Primary citation: Appleton, B.A.,Wu, P.,Maloney, J.,Yin, J.,Liang, W.C.,Stawicki, S.,Mortara, K.,Bowman, K.K.,Elliott, J.M.,Desmarais, W.,Bazan, J.F.,Bagri, A.,Tessier-Lavigne, M.,Koch, A.W.,Wu, Y.,Watts, R.J.,Wiesmann, C.; Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding; Embo J., 26:4902-4912, 2007; PubMed: 17989695; DOI: 10.1038/sj.emboj.7601906

Experimental method

X-RAY DIFFRACTION (3.1 Å)