2QQL
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| L | 0002250 | biological_process | adaptive immune response |
| L | 0002376 | biological_process | immune system process |
| L | 0003823 | molecular_function | antigen binding |
| L | 0005576 | cellular_component | extracellular region |
| L | 0005615 | cellular_component | extracellular space |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006955 | biological_process | immune response |
| L | 0016064 | biological_process | immunoglobulin mediated immune response |
| L | 0019814 | cellular_component | immunoglobulin complex |
| L | 0050853 | biological_process | B cell receptor signaling pathway |
| L | 0070062 | cellular_component | extracellular exosome |
| L | 0071735 | cellular_component | IgG immunoglobulin complex |
| L | 0071738 | cellular_component | IgD immunoglobulin complex |
| L | 0071742 | cellular_component | IgE immunoglobulin complex |
| L | 0071745 | cellular_component | IgA immunoglobulin complex |
| L | 0071753 | cellular_component | IgM immunoglobulin complex |
| L | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR194-HIS200 |
| site_id | PS01285 |
| Number of Residues | 30 |
| Details | FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. GWtpnldsnke......YLqVDlrfltmLtaIaTQG |
| Chain | Residue | Details |
| A | GLY317-GLY346 | |
| A | GLY473-GLY505 |
| site_id | PS01286 |
| Number of Residues | 17 |
| Details | FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pqtwhsgia..LRlELfGC |
| Chain | Residue | Details |
| A | PRO411-CYS427 | |
| A | PRO575-CYS592 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 114 |
| Details | Domain: {"description":"CUB 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 150 |
| Details | Domain: {"description":"F5/8 type C 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17989695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QQO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17989695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QQK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
