4WMJ
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1AG7
| CONOTOXIN GS, NMR, 20 STRUCTURES | Descriptor: | CONOTOXIN GS | Authors: | Hill, J.M, Alewood, P.F, Craik, D.J. | Deposit date: | 1997-04-03 | Release date: | 1998-04-08 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry. Structure, 5, 1997
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1EYO
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5MHF
| Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin. | Descriptor: | 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mannosyl-oligosaccharide glucosidase, ... | Authors: | Hill, J.C, Caputo, A.T, Roversi, P, Zitzmann, N. | Deposit date: | 2016-11-24 | Release date: | 2017-12-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Targeting Endoplasmic Reticulum alpha-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections. J.Med.Chem., 2020
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1MII
| SOLUTION STRUCTURE OF ALPHA-CONOTOXIN MII | Descriptor: | PROTEIN (ALPHA CONOTOXIN MII) | Authors: | Hill, J.M, Oomen, C.J, Miranda, L.P, Bingham, J.P, Alewood, P.F, Craik, D.J. | Deposit date: | 1998-10-05 | Release date: | 1998-10-21 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity. Biochemistry, 37, 1998
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1GIB
| MU-CONOTOXIN GIIIB, NMR | Descriptor: | MU-CONOTOXIN GIIIB | Authors: | Hill, J.M, Alewood, P.F, Craik, D.J. | Deposit date: | 1996-04-17 | Release date: | 1996-11-08 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry, 35, 1996
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1N3K
| Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) | Descriptor: | Astrocytic phosphoprotein PEA-15 | Authors: | Hill, J.M, Vaidyanathan, H, Ramos, J.W, Ginsberg, M.H, Werner, M.H. | Deposit date: | 2002-10-28 | Release date: | 2003-01-14 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain Embo J., 21, 2002
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7ZXK
| Human IL-27 in complex with neutralizing SRF388 FAb fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, ... | Authors: | Bloch, Y, Skladanowska, K, Strand, J, Welin, M, Logan, D, Hill, J, Savvides, S.N. | Deposit date: | 2022-05-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41, 2022
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5MU1
| UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum soaked with K2PtI6 | Descriptor: | CALCIUM ION, IODIDE ION, PLATINUM (II) ION, ... | Authors: | Roversi, P, Caputo, A.T, Hill, J, Alonzi, D.S, Zitzmann, N. | Deposit date: | 2017-01-11 | Release date: | 2017-07-26 | Last modified: | 2023-03-08 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5MZO
| UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum (open conformation) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Roversi, P, Caputo, A.T, Hill, J, Alonzi, D.S, Zitzmann, N. | Deposit date: | 2017-02-01 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5N2J
| UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum (closed form) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Roversi, P, Caputo, A.T, Hill, J, Alonzi, D.S, Zitzmann, N. | Deposit date: | 2017-02-07 | Release date: | 2017-07-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8Q3L
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5A0E
| Crystal structure of cyclophilin D in complex with CsA analogue, JW47. | Descriptor: | JW47, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL | Authors: | Warne, J, Pryce, G, Hill, J, Shi, X, Lenneras, F, Puentes, F, Kip, M, Hilditch, L, Walker, P, Simone, M, Chan, A.W.E, Towers, G, Coker, A.R, Duchen, M, Szabadkai, G, Baker, D, Selwood, D.L. | Deposit date: | 2015-04-19 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis. J.Biol.Chem., 291, 2016
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4I1K
| Crystal Structure of VRN1 (Residues 208-341) | Descriptor: | B3 domain-containing transcription factor VRN1, CHLORIDE ION | Authors: | King, G, Chanson, A.H, McCallum, E.J, Ohme-Takagi, M, Byriel, K, Hill, J.M, Martin, J.L, Mylne, J.S. | Deposit date: | 2012-11-21 | Release date: | 2012-12-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Arabidopsis B3 Domain Protein VERNALIZATION1 (VRN1) Is Involved in Processes Essential for Development, with Structural and Mutational Studies Revealing Its DNA-binding Surface. J.Biol.Chem., 288, 2013
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2KYJ
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5YIG
| Crystal structure of Streptococcus pneumonia ParE with inhibitor | Descriptor: | 1-ethyl-3-[5-[2-[(1S,5R)-3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-(2-oxidanylidene-3H-1,3,4-oxadiazol-5-yl)pyridin-3-yl]-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]pyridin-2-yl]urea, DNA topoisomerase 4 subunit B | Authors: | Cherian, J, Tan, Y, Hill, J. | Deposit date: | 2017-10-04 | Release date: | 2018-09-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Eur J Med Chem, 157, 2018
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5BOD
| Crystal structure of Streptococcus pneumonia ParE inhibitor | Descriptor: | (2R)-N-[3-(3,5-dimethylphenyl)-1H-pyrazol-5-yl]-1,4-dioxane-2-carboxamide, DNA topoisomerase 4 subunit B | Authors: | Tan, Y.W, Chen, G, Hung, A.W, Hill, J. | Deposit date: | 2015-05-27 | Release date: | 2015-06-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Application of Fragment-based Drug Discovery against DNA GyraseB to be published
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5BOC
| Crystal structure of topoisomerase ParE inhibitor | Descriptor: | 3-methyl-4-({3-[3-methyl-5-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)benzoic acid, DNA topoisomerase 4 subunit B | Authors: | Tan, Y.W, Chen, G.Y, Hung, A.W, Hill, J. | Deposit date: | 2015-05-27 | Release date: | 2015-06-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Application of Fragment-based Drug Discovery against DNA GyraseB To be published
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1VTP
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6AFK
| Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | Descriptor: | N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide, S-ADENOSYLMETHIONINE, tRNA (guanine-N(1)-)-methyltransferase | Authors: | Zhong, W, Koay, A, Wong, Y.W, Sahili, A.E, Nah, Q, Kang, C, Poulsen, A, Chionh, Y.K, McBee, M, Matter, A, Hill, J, Lescar, J, Dedon, P.C. | Deposit date: | 2018-08-08 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors. Acs Infect Dis., 5, 2019
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6JLR
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8BD0
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8BPI
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2MPC
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6ILZ
| Crystal structure of PKCiota in complex with inhibitor | Descriptor: | 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl)pyridine-3-carboxamide, Protein kinase C iota type | Authors: | Baburajendran, N, Hill, J. | Deposit date: | 2018-10-21 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.261 Å) | Cite: | Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. Acs Med.Chem.Lett., 10, 2019
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