2MPC

Solution structure of the pyrin domain of human Pyrin

Summary for 2MPC

• Entry DOI: 10.2210/pdb2mpc/pdb
• NMR Information: BMRB: 19875
• Descriptor: Pyrin (1 entity in total)
• Functional Keywords: pyrin domain, death domain, inflammation, cs-rosetta, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Cytoplasm, cytoskeleton. Isoform 2: Nucleus: O15553
• Total number of polymer chains: 1
• Total formula weight: 11826.58

Authors

Soh, S.L.,Smith, S.J.,Hill, J.M. (deposition date: 2014-05-15, release date: 2014-07-16, Last modification date: 2022-08-24)

• Primary citation: Vajjhala, P.R.,Kaiser, S.,Smith, S.J.,Ong, Q.R.,Soh, S.L.,Stacey, K.J.,Hill, J.M.; Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.; J.Biol.Chem., 289:23504-23519, 2014; PubMed: 25006247; DOI: 10.1074/jbc.M114.553305

Experimental method

SOLUTION NMR