8IUL
| Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex | 分子名称: | Antibody fragment scFv16, G subunit alpha (q), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wu, C, Xu, Y, Xu, H.E. | 登録日 | 2023-03-24 | 公開日 | 2023-07-12 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor. Nat Commun, 14, 2023
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8H8J
| Lodoxamide-bound GPR35 in complex with G13 | 分子名称: | 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid), CALCIUM ION, CHOLESTEROL, ... | 著者 | Yuan, Q, Duan, J, Liu, Q, Xu, H.E, Jiang, Y. | 登録日 | 2022-10-23 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell Discov, 8, 2022
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7C2E
| GLP-1R-Gs complex structure with a small molecule full agonist | 分子名称: | 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. | 登録日 | 2020-05-07 | 公開日 | 2020-08-26 | 最終更新日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30, 2020
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7D77
| Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | 著者 | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | 登録日 | 2020-10-03 | 公開日 | 2021-02-03 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
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7D76
| Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex | 分子名称: | (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | 著者 | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | 登録日 | 2020-10-03 | 公開日 | 2021-02-03 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
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7W57
| Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | You, C, Xu, H.E, Jiang, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-04-20 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022
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7W56
| Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | You, C, Xu, H.E, Jiang, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-04-20 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022
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7W55
| Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | You, C, Xu, H.E, Jiang, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-04-20 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022
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7W53
| Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | You, C, Xu, H.E, Jiang, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-04-20 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022
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8GY7
| Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | 分子名称: | CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. | 登録日 | 2022-09-21 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Res., 33, 2023
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3GCB
| GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454 | 分子名称: | GAL6, GLYCEROL, SULFATE ION | 著者 | Joshua-Tor, L, Zheng, W, Johnston, S.A. | 登録日 | 1998-02-27 | 公開日 | 1998-10-21 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell(Cambridge,Mass.), 93, 1998
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7WQ4
| Galanin-bound galanin receptor 2 in complex with Gq | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-04-20 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7WQ3
| Galanin-bound galanin receptor 1 in complex with Gi | 分子名称: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | 登録日 | 2022-01-24 | 公開日 | 2022-04-20 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7DUQ
| Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-01-11 | 公開日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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7DUR
| Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-01-11 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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7EVM
| Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-05-21 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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8ID9
| Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | 分子名称: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID6
| Cryo-EM structure of the oleic acid bound GPR120-Gi complex | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID4
| Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID3
| Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | 分子名称: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID8
| Cryo-EM structure of the TUG891 bound GPR120-Gi complex | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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7E14
| Compound2_GLP-1R_OWL833_Gs complex structure | 分子名称: | 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, CHOLESTEROL, G protein, ... | 著者 | Cong, Z.T, Chen, L.N, Ma, H.L, Yang, D.H, Xu, H.E, Zhang, Y, Wang, M.W. | 登録日 | 2021-01-30 | 公開日 | 2021-07-07 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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8IF6
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8HBD
| Cryo-EM structure of IRL1620-bound ETBR-Gi complex | 分子名称: | Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. | 登録日 | 2022-10-28 | 公開日 | 2023-03-22 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
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8HCX
| Cryo-EM structure of Endothelin1-bound ETBR-Gq complex | 分子名称: | Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. | 登録日 | 2022-11-03 | 公開日 | 2023-03-22 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
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