8IUL

Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex

Summary for 8IUL

• Entry DOI: 10.2210/pdb8iul/pdb
• EMDB information: 35725
• Descriptor: G subunit alpha (q), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Antibody fragment scFv16, ... (6 entities in total)
• Functional Keywords: gpcr, ptgfr, latanoprost, gq, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 154121.19

Authors

Wu, C.,Xu, Y.,Xu, H.E. (deposition date: 2023-03-24, release date: 2023-07-12, Last modification date: 2023-08-30)

• Primary citation: Wu, C.,Xu, Y.,He, Q.,Li, D.,Duan, J.,Li, C.,You, C.,Chen, H.,Fan, W.,Jiang, Y.,Eric Xu, H.; Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor.; Nat Commun, 14:2668-2668, 2023; PubMed: 37160891; DOI: 10.1038/s41467-023-38411-x

Experimental method

ELECTRON MICROSCOPY (2.78 Å)