8ID6

Cryo-EM structure of the oleic acid bound GPR120-Gi complex

Summary for 8ID6

• Entry DOI: 10.2210/pdb8id6/pdb
• EMDB information: 35358
• Descriptor: Free fatty acid receptor 4, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, gpr120, complex, fatty acid hormones, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 156740.62

Authors

Mao, C.,Xiao, P.,Tao, X.,Qin, J.,He, Q.,Zhang, C.,Yu, X.,Zhang, Y.,Sun, J. (deposition date: 2023-02-12, release date: 2023-03-15, Last modification date: 2023-05-03)

• Primary citation: Mao, C.,Xiao, P.,Tao, X.N.,Qin, J.,He, Q.T.,Zhang, C.,Guo, S.C.,Du, Y.Q.,Chen, L.N.,Shen, D.D.,Yang, Z.S.,Zhang, H.Q.,Huang, S.M.,He, Y.H.,Cheng, J.,Zhong, Y.N.,Shang, P.,Chen, J.,Zhang, D.L.,Wang, Q.L.,Liu, M.X.,Li, G.Y.,Guo, Y.,Xu, H.E.,Wang, C.,Zhang, C.,Feng, S.,Yu, X.,Zhang, Y.,Sun, J.P.; Unsaturated bond recognition leads to biased signal in a fatty acid receptor.; Science, 380:eadd6220-eadd6220, 2023; PubMed: 36862765; DOI: 10.1126/science.add6220

Experimental method

ELECTRON MICROSCOPY (2.8 Å)