7EVM

Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex

Summary for 7EVM

• Entry DOI: 10.2210/pdb7evm/pdb
• EMDB information: 30867 31329
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: glucagon-like peptide-1 receptor, ago-allosteric modulator, type 2 diabetes, compound 2, class b gpcr, biosynthetic protein, structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 160122.78

Authors

Cong, Z.,Chen, L.,Ma, H.,Zhou, Q.,Zou, X.,Ye, C.,Dai, A.,Liu, Q.,Huang, W.,Sun, X.,Wang, X.,Xu, P.,Zhao, L.,Xia, T.,Zhong, W.,Yang, D.,Xu, H.E.,Zhang, Y.,Wang, M. (deposition date: 2021-05-21, release date: 2021-08-11)

• Primary citation: Cong, Z.,Chen, L.N.,Ma, H.,Zhou, Q.,Zou, X.,Ye, C.,Dai, A.,Liu, Q.,Huang, W.,Sun, X.,Wang, X.,Xu, P.,Zhao, L.,Xia, T.,Zhong, W.,Yang, D.,Eric Xu, H.,Zhang, Y.,Wang, M.W.; Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.; Nat Commun, 12:3763-3763, 2021; PubMed: 34145245; DOI: 10.1038/s41467-021-24058-z

Experimental method

ELECTRON MICROSCOPY (2.5 Å)