7EVM
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Summary for 7EVM
Entry DOI | 10.2210/pdb7evm/pdb |
EMDB information | 30867 31329 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | glucagon-like peptide-1 receptor, ago-allosteric modulator, type 2 diabetes, compound 2, class b gpcr, biosynthetic protein, structural protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 160122.78 |
Authors | |
Primary citation | Cong, Z.,Chen, L.N.,Ma, H.,Zhou, Q.,Zou, X.,Ye, C.,Dai, A.,Liu, Q.,Huang, W.,Sun, X.,Wang, X.,Xu, P.,Zhao, L.,Xia, T.,Zhong, W.,Yang, D.,Eric Xu, H.,Zhang, Y.,Wang, M.W. Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12:3763-3763, 2021 Cited by PubMed: 34145245DOI: 10.1038/s41467-021-24058-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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