7W55

Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex

Summary for 7W55

• Entry DOI: 10.2210/pdb7w55/pdb
• EMDB information: 32314
• Descriptor: Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Neuromedin-U-25, ... (6 entities in total)
• Functional Keywords: cryo-em, gpcr, neuromedin u, neuromedin u receptor 2, gq, complex, signaling protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 182467.19

Authors

You, C.,Xu, H.E.,Jiang, Y. (deposition date: 2021-11-29, release date: 2022-04-20, Last modification date: 2022-06-15)

• Primary citation: You, C.,Zhang, Y.,Xu, P.,Huang, S.,Yin, W.,Eric Xu, H.,Jiang, Y.; Structural insights into the peptide selectivity and activation of human neuromedin U receptors.; Nat Commun, 13:2045-2045, 2022; PubMed: 35440625; DOI: 10.1038/s41467-022-29683-w

Experimental method

ELECTRON MICROSCOPY (2.8 Å)