8HCX

Cryo-EM structure of Endothelin1-bound ETBR-Gq complex

Summary for 8HCX

• Entry DOI: 10.2210/pdb8hcx/pdb
• EMDB information: 34667
• Descriptor: Guanine nucleotide-binding protein G(q) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, ... (6 entities in total)
• Functional Keywords: et1, etar, gq, scfv16, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 177745.16

Authors

Yuan, Q.,Jiang, Y.,Xu, H.E.,Ji, Y.,Duan, J. (deposition date: 2022-11-03, release date: 2023-03-22, Last modification date: 2023-10-04)

• Primary citation: Ji, Y.,Duan, J.,Yuan, Q.,He, X.,Yang, G.,Zhu, S.,Wu, K.,Hu, W.,Gao, T.,Cheng, X.,Jiang, H.,Eric Xu, H.,Jiang, Y.; Structural basis of peptide recognition and activation of endothelin receptors.; Nat Commun, 14:1268-1268, 2023; PubMed: 36882417; DOI: 10.1038/s41467-023-36998-9

Experimental method

ELECTRON MICROSCOPY (3.5 Å)